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The Osteoporosis Research Programme was formed in 1990 by academic staff members from Department of Community and Family Medicine, Department of Orthopaedics & Traumatology, Department of Medicine and Therapeutic, Department of Obstetrics & Gynaecology and Department of Paediatrics. The mission was to conduct multidisciplinary research, and to address the problem of osteoporosis from childhood, through adolescent, the menopause and old age. A comprehensive programme was developed to embrace edpidemology, clinical trails, genetic and biomechanics research.
1. Epidemiological Studies
Epidemiological studies are essential in allowing an understanding of disease burden, ethnic difference and risk factors for osteoporosis. They form the basis for preventive and control programmes.
Project of major Impact
Ongoing projects of major impact
2. Genetic and Genome Studies
Gene may determine 80% of the variability in bone mass; and genome studies have the potential to be applied to genetic screening, case finding as well as gene therapy.
Genetic Linkage and Polymorphism Studies – Candidate gene studies search for an association between a polymorphism and a phenotype such as BMD. The following genes are under massive investigation:
With recent advances in Human Genome Project & biotechnology such as small nucleotide polymorphism maps, we are now able to perform allelic association studies on whole genome search. This should eventually lead to better prevention strategies and more receptor-based therapies against osteoporosis.
Selected Projects of Major Impact
Ongoing Projects of Major Impact
3. Clinical Trials
Clinical trials, particularly trials pertaining to drug development, form the foundation for therapeutics in osteoporosis. Clinical trials can also be applied to evaluate preventive measures, and to develop evidence-based recommendations.
Ongoing phase III studies
Selected Projects of Major Impact
Ongoing Projects of Major Impact
4. Biomechanic Studies
An understanding of bone geometry, bone structure, bone strength is essential for fracture prevention.
Selected projects of major impact
Ongoing projects of major impact
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Last revision date: Jun 2018